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inner nuclear membrane protein
Inner nuclear membrane (INM) proteins are proteins that are embedded in or associated with the inner membrane of the nuclear envelope (NE). There are about 60 INM proteins, most of which are poorly characterized with respect to structure and function. Among the few well-characterized INM proteins are lamin B receptor (LBR), the lamina-associated polypeptide 1 (LAP1), the lamina-associated polypeptide-2 (LAP2), emerin and MAN1.
==Common structural features==
There have been identified several integral nuclear membrane proteins of different size and structure. It is proposed that they share some structural features with respect to nucleoplasmic domain(s) and lipid-soluble domain(s). Some INM proteins contain common protein domain structures, and can thus be categorised into known protein domain families. These include the LEM-, SUN-, and KASH-domain families. Members of the LEM-domain family play a part in chromatin organisation. SUN- and KASH-domains participate in linking the cytoskeleton and nucleoskeleton through the LINC complex.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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